1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone O-tosyl oxime

Base Information

Chemical Name:1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone O-tosyl oxime
CAS No.:162844-89-5
Molecular Formula:C₂₂H₂₈F₃NO₄SSi
Molecular Weight:487.615
Hs Code.:

Synonyms:1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone O-tosyl oxime

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Chemical Property of 1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone O-tosyl oxime

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Technology Process of 1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone O-tosyl oxime

There total 5 articles about 1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone O-tosyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 162844-88-4
1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone oxime

: 98-59-9
p-toluenesulfonyl chloride

: 162844-89-5
1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone O-tosyl oxime

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.chembiol.2019.03.008

Reference yield:

: 15852-73-0
(3-Bromophenyl)methanol

: 162844-89-5
1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone O-tosyl oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 2 h / -78 °C

3.1: hydroxylamine hydrochloride; pyridine / ethanol / 3 h / Reflux

4.1: dmap; triethylamine / dichloromethane / 0 °C

With pyridine; dmap; n-butyllithium; hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane;

Reference yield:

: 103978-12-7
[(3-bromobenzyl)oxy](tert-butyl)dimethylsilane

: 162844-89-5
1-(3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,2-trifluoroethanone O-tosyl oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: hydroxylamine hydrochloride; pyridine / ethanol / 3 h / Reflux

3.1: dmap; triethylamine / dichloromethane / 0 °C

With pyridine; dmap; n-butyllithium; hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane;