(4-(3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(4-(3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone
CAS No.:1464151-21-0
Molecular Formula:C₂₆H₂₄N₆O
Molecular Weight:436.516
Hs Code.:

Synonyms:(4-(3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

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Chemical Property of (4-(3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

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Technology Process of (4-(3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

There total 5 articles about (4-(3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1464155-32-5
(4-(3-bromoimidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

: 144104-59-6
1H-indole-5-boronic acid

: 1464151-21-0
(4-(3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 110 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 14047-29-1
4-carboxyphenylboronic acid

: 1464151-21-0
(4-(3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,4-dioxane / 6 h / 20 °C / Inert atmosphere; Reflux

2.1: N-Bromosuccinimide / acetonitrile / 3 h / 0 °C

3.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 0.5 h / 110 °C / Microwave irradiation

With 4-methyl-morpholine; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1084953-10-5
4-(3-bromoimidazo[1,2-b]pyridazin-6-yl)benzoic acid

: 1464151-21-0
(4-(3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 0.5 h / 110 °C / Microwave irradiation

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;