(2S,3S)-2-Phenyl-3-(propan-2-yl)aziridine

Base Information

• Chemical Name: (2S,3S)-2-Phenyl-3-(propan-2-yl)aziridine
• CAS No.: 73475-45-3
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.247
• DSSTox Substance ID: DTXSID00703620
• Wikidata: Q82635816
• Mol file: 73475-45-3.mol

Synonyms:73475-45-3;(2S,3S)-2-Phenyl-3-(propan-2-yl)aziridine;DTXSID00703620;(2R,3S)-2-phenyl-3-propan-2-ylaziridine;EN300-366751;rac-(2R,3R)-2-phenyl-3-(propan-2-yl)aziridine;2089245-84-9

Chemical Property of (2S,3S)-2-Phenyl-3-(propan-2-yl)aziridine

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 161.120449483
• Heavy Atom Count: 12
• Complexity: 147

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)C1C(N1)C2=CC=CC=C2
• Isomeric SMILES: CC(C)[C@H]1[C@@H](N1)C2=CC=CC=C2

Technology Process of (2S,3S)-2-Phenyl-3-(propan-2-yl)aziridine

There total 2 articles about (2S,3S)-2-Phenyl-3-(propan-2-yl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-(3-methylbut-1-en-1-yl)benzene (15325-61-8,1608-28-2,15325-56-1) + 2-trimethylsilanyl-ethanesulfonyl chloride (106018-85-3) → (2S,3S)-2-isopropyl-3-phenylaziridine (53932-93-7,73475-45-3,420087-35-0) + (2R,3R)-2-isopropyl-3-phenylaziridine (420087-35-0)

Guidance literature:

(E)-(3-methylbut-1-en-1-yl)benzene; 2-trimethylsilanyl-ethanesulfonyl chloride; With pyridine N-oxide; [(R,R)-1,2-(N=CHC₆H₄O-o)2-cyclohexane]MnN; silver perchlorate; In pyridine; dichloromethane; at 0 ℃; for 12h;

With tris(dimethylamino)sulfonium trimethylsilyldifluoride; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/jo016146d

Reference yield:

→ (2R,3S)-2-Isopropyl-3-phenyl-aziridine (53932-93-7,73475-45-3)

Guidance literature:

Oxim 4, i-BuMgBr;

upstream raw materials:

(E)-(3-methylbut-1-en-1-yl)benzene

2-trimethylsilanyl-ethanesulfonyl chloride

Refernces