Technology Process of (2S,3S)-2-(2-(tert-butoxy)-2-oxoethyl)-3-phenylhex-5-enoic acid
There total 4 articles about (2S,3S)-2-(2-(tert-butoxy)-2-oxoethyl)-3-phenylhex-5-enoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3S,4S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-4-phenylhept-6-enoate;
With
dihydrogen peroxide;
In
tetrahydrofuran; water;
for 0.416667h;
Inert atmosphere;
With
lithium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.0833333h;
With
sodium sulfite;
In
tetrahydrofuran; water;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4-but-1-enylmagnesium bromide / copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
2.2: 0.83 h / -78 °C
3.1: dihydrogen peroxide / water; tetrahydrofuran / 0.42 h / Inert atmosphere
3.2: 0.08 h / 20 °C
3.3: Cooling with ice
With
dihydrogen peroxide; 4-but-1-enylmagnesium bromide; sodium hexamethyldisilazane;
copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
1.2: 1.5 h / -78 - 0 °C
2.1: 4-but-1-enylmagnesium bromide / copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
3.2: 0.83 h / -78 °C
4.1: dihydrogen peroxide / water; tetrahydrofuran / 0.42 h / Inert atmosphere
4.2: 0.08 h / 20 °C
4.3: Cooling with ice
With
n-butyllithium; dihydrogen peroxide; 4-but-1-enylmagnesium bromide; sodium hexamethyldisilazane;
copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran; hexane; water;
