N-{2-[5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide

Base Information

Chemical Name:N-{2-[5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide
CAS No.:866363-60-2
Molecular Formula:C₂₁H₁₉N₃O₄
Molecular Weight:377.4
Hs Code.:

Synonyms:N-{2-[5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide

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Chemical Property of N-{2-[5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide

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Technology Process of N-{2-[5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide

There total 3 articles about N-{2-[5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1430737-21-5
N-{2-[7-benzyl-5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide

: 866363-60-2
N-{2-[5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide

Guidance literature:: With ammonium formate; palladium; In ethanol; for 15h; Reflux;
DOI:10.1016/j.tet.2013.03.052

Reference yield:

: C₃₅H₃₁N₃O₅

: 866363-60-2
N-{2-[5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 24 h / Reflux

2: palladium; ammonium formate / ethanol / 15 h / Reflux

With ammonium formate; palladium; triethylamine; In ethanol;
DOI:10.1016/j.tet.2013.03.052

Reference yield:

: 1430737-16-8
N-{2-[7-benzyl-5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylcarbamic acid tert-butyl ester

: 866363-60-2
N-{2-[5-(4-benzyloxyphenyl)-1-methyl-4,8-dioxo-1,4,7,8-tetrahydropyrrolo[3,2-f]indol-3-yl]ethyl}-N-methylformamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

2: triethylamine / 24 h / Reflux

3: palladium; ammonium formate / ethanol / 15 h / Reflux

With ammonium formate; palladium; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2013.03.052