(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester

Base Information

Chemical Name:(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester
CAS No.:161979-03-9
Molecular Formula:C₃₆H₆₁IN₂O₈Si
Molecular Weight:804.879
Hs Code.:

(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester

Synonyms:(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester

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Chemical Property of (R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester

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Technology Process of (R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester

There total 6 articles about (R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 160531-32-8
(R)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-((tert-butyldimethylsilyl)oxy)-3-iodophenyl)propanoic acid

: 161979-02-8
(9-Hydroxy-nonanoylamino)-acetic acid tert-butyl ester

: 161979-03-9
(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at -20 ℃; for 0.666667h;
DOI:10.1016/S0040-4020(01)81206-0

Reference yield:

: 3937-56-2
1,9-Nonanediol

: 161979-03-9
(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 52 percent / 60percent NaH / tetrahydrofuran; hexane / 1.5 h / Ambient temperature

2: 42.7 mg / SO₃*pyridine, Et₃N / dimethylsulfoxide / 16 h / Ambient temperature

3: 80percent NaClO₂, NaHPO₄*2H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0.17 h / Ambient temperature

4: 93 percent / DEPC, Et₃N / dimethylformamide / 0.67 h / 0 °C

5: 99 percent / 47percent aq. HF / acetonitrile / 0.33 h / 0 °C

6: 95 percent / DCC, DMAP / CH₂Cl₂ / 0.67 h / -20 °C

With dmap; sodium chlorite; 2-methyl-but-2-ene; pyridine-SO₃ complex; hydrogen fluoride; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; diethyl dicarbonate; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)81206-0

Reference yield:

: 157730-99-9
9-(tert-butyldimethylsilanyloxy)-1-nonanol

: 161979-03-9
(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionic acid 8-(tert-butoxycarbonylmethyl-carbamoyl)-octyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 42.7 mg / SO₃*pyridine, Et₃N / dimethylsulfoxide / 16 h / Ambient temperature

2: 80percent NaClO₂, NaHPO₄*2H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0.17 h / Ambient temperature

3: 93 percent / DEPC, Et₃N / dimethylformamide / 0.67 h / 0 °C

4: 99 percent / 47percent aq. HF / acetonitrile / 0.33 h / 0 °C

5: 95 percent / DCC, DMAP / CH₂Cl₂ / 0.67 h / -20 °C

With dmap; sodium chlorite; 2-methyl-but-2-ene; pyridine-SO₃ complex; hydrogen fluoride; triethylamine; dicyclohexyl-carbodiimide; diethyl dicarbonate; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)81206-0