(4R,8R,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltridecyl diisopropylcarbamate

Base Information

Chemical Name:(4R,8R,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltridecyl diisopropylcarbamate
CAS No.:1623736-71-9
Molecular Formula:C₃₉H₆₅NO₄Si
Molecular Weight:640.035
Hs Code.:

Synonyms:(4R,8R,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltridecyl diisopropylcarbamate

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Chemical Property of (4R,8R,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltridecyl diisopropylcarbamate

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Technology Process of (4R,8R,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltridecyl diisopropylcarbamate

There total 14 articles about (4R,8R,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltridecyl diisopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1623736-65-1
(4S,6E,8S,10E,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltrideca-6,10-dien-1-yl diisopropylcarbamate

: 1623736-71-9
(4R,8R,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltridecyl diisopropylcarbamate

Guidance literature:: With platinum(IV) oxide; hydrogen; In ethyl acetate; for 22.0833h;
DOI:10.1002/anie.201400714

Reference yield:

: (4S,6E,8R,10E,12R)-13-((tert-butyldiphenylsilyl)oxy)-4,8,12-trimethyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)trideca-6,10-dien-1-yl diisopropylcarbamate

: 1623736-71-9
(4R,8R,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltridecyl diisopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0.5 h / 0 °C

2: hydrogen; platinum(IV) oxide / ethyl acetate / 22.08 h

With platinum(IV) oxide; hydrogen; dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1002/anie.201400714

Reference yield:

: 1623736-61-7
(R,E)-tert-butyl((2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pent-3-en-1-yl)oxy)diphenylsilane

: 1623736-71-9
(4R,8R,12R)-13-((tert-butyldiphenylsilyl)oxy)-8-hydroxy-4,8,12-trimethyltridecyl diisopropylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec.-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane; diethyl ether / -78 °C / Inert atmosphere

1.2: 0.53 h / -78 °C / Inert atmosphere

2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0.5 h / 0 °C

3.1: hydrogen; platinum(IV) oxide / ethyl acetate / 22.08 h

With platinum(IV) oxide; N,N,N,N,-tetramethylethylenediamine; hydrogen; dihydrogen peroxide; sec.-butyllithium; sodium hydroxide; In tetrahydrofuran; diethyl ether; hexane; water; ethyl acetate;
DOI:10.1002/anie.201400714