N-(3-(2-bromo-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Base Information

Chemical Name:N-(3-(2-bromo-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide
CAS No.:1160625-04-6
Molecular Formula:C₂₀H₁₀BrClF₂N₄OS
Molecular Weight:507.745
Hs Code.:

Synonyms:N-(3-(2-bromo-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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Chemical Property of N-(3-(2-bromo-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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Technology Process of N-(3-(2-bromo-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

There total 1 articles about N-(3-(2-bromo-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1160623-16-4
N-(3-(2-amino-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluoro-benzamide

: 1160625-04-6
N-(3-(2-bromo-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Guidance literature:: N-(3-(2-amino-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluoro-benzamide; With tert.-butylnitrite; In acetonitrile; at 0 ℃; for 0.0166667h;

With copper(ll) bromide; In acetonitrile; for 0.25h;

Reference yield: 70.0%

: 1160625-04-6
N-(3-(2-bromo-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

: 544-97-8
dimethyl zinc(II)

: 1160625-05-7
N-(3-(5-(2-chloro-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene; at 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 25.0%

: 1160625-04-6
N-(3-(2-bromo-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1160626-26-5
N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(4-hydroxyphenyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 70 ℃; for 13h;