methyl 3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propionate

Base Information

• Chemical Name: methyl 3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propionate
• CAS No.: 1042722-99-5
• Molecular Formula: C₁₉H₁₈FNO₄
• Molecular Weight: 343.355

Synonyms:methyl 3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propionate

Chemical Property of methyl 3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propionate

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Technology Process of methyl 3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propionate

There total 1 articles about methyl 3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoate (204589-80-0) → methyl 3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propionate (1042722-99-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In water; ethyl acetate; for 20h; under 2625.26 Torr;

Reference yield: 85.0%

methyl 3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propionate (1042722-99-5) + 1-bromomethyl-4-bromobenzene (589-15-1) → methyl 3-{(2S,3R)-2-[4-(4-bromobenzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl}propionate (1042723-03-4)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone; for 3.5h; Heating / reflux;

Reference yield: 78.0%

methyl 3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propionate (1042722-99-5) + p-Methoxybenzyl bromide (2746-25-0) → methyl 3-{(2S,3R)-1-(4-fluorophenyl)-2-[4-(4-methoxybenzyloxy)phenyl]-4-oxoazetidin-3-yl}propionate (1042723-07-8)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone; for 5h; Heating / reflux;

upstream raw materials:

methyl 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoate

Downstream raw materials:

methyl 3-{(2S,3R)-2-[4-(4-bromobenzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl}propionate

methyl 3-{(2S,3R)-1-(4-fluorophenyl)-2-[4-(4-methoxybenzyloxy)phenyl]-4-oxoazetidin-3-yl}propionate

methyl 3-{(2S,3R)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl}propionate

methyl 3-{(3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]azetidin-3-yl}propanoate

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