Technology Process of 3-(Benzyloxy)-7,8-didehydro-4,5α-epoxy-14β-methoxy-17-methylmorphinan-6-one
There total 8 articles about 3-(Benzyloxy)-7,8-didehydro-4,5α-epoxy-14β-methoxy-17-methylmorphinan-6-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
for 20h;
Ambient temperature;
DOI:10.1002/hlca.19900730622
- Guidance literature:
-
3-O-benzyl-14-hydroxymorphinone;
With
sodium hydride;
In
N,N-dimethyl-formamide; Petroleum ether;
for 0.5h;
Inert atmosphere;
Cooling with ice bath;
dimethyl sulfate;
In
N,N-dimethyl-formamide; Petroleum ether;
for 2h;
Inert atmosphere;
Cooling with ice bath;
With
sodium hydride;
In
N,N-dimethyl-formamide; Petroleum ether;
for 1h;
Inert atmosphere;
Cooling with ice bath;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; Petroleum ether / 0.5 h / Inert atmosphere; Cooling with ice bath
2.2: 2 h / Inert atmosphere; Cooling with ice bath
2.3: 1 h / Inert atmosphere; Cooling with ice bath
With
sodium hydride; potassium carbonate;
In
N,N-dimethyl-formamide; Petroleum ether;