methyl 3-(5-methoxypyridin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate

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Chemical Name:methyl 3-(5-methoxypyridin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate
CAS No.:1401348-58-0
Molecular Formula:C₂₂H₁₉N₃O₅S
Molecular Weight:437.476
Hs Code.:

Synonyms:methyl 3-(5-methoxypyridin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate

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Chemical Property of methyl 3-(5-methoxypyridin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate

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Technology Process of methyl 3-(5-methoxypyridin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate

There total 5 articles about methyl 3-(5-methoxypyridin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.1%

: 445264-60-8
3-methoxy-5-pyridineboronic acid pinacol ester

: 1401348-55-7
methyl 3-iodo-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate

: 1401348-58-0
methyl 3-(5-methoxypyridin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate

Guidance literature:: With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In water; isopropyl alcohol; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 872355-64-1
1H-pyrrolo[3,2-b]pyridine-5-carboxylic acid

: 1401348-58-0
methyl 3-(5-methoxypyridin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

4.1: dichloromethane / 0 °C

5.1: potassium phosphate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / isopropyl alcohol; water / 0.17 h / 100 °C / Microwave irradiation

With potassium phosphate; oxalyl dichloride; iodine; sodium hydride; potassium hydroxide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); N,N-dimethyl-formamide; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 1190311-30-8
3-iodo-1H-pyrrolo[3,2-b]pyridine-5-carboxylic acid

: 1401348-58-0
methyl 3-(5-methoxypyridin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3.1: dichloromethane / 0 °C

4.1: potassium phosphate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / isopropyl alcohol; water / 0.17 h / 100 °C / Microwave irradiation

With potassium phosphate; oxalyl dichloride; sodium hydride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); N,N-dimethyl-formamide; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;