1-(4-nitro-phenyl)-2-oxo-5-(2-pyrrolidin-1-yl-ethyl)-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

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Chemical Name:1-(4-nitro-phenyl)-2-oxo-5-(2-pyrrolidin-1-yl-ethyl)-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile
CAS No.:698396-39-3
Molecular Formula:C₂₄H₂₁N₅O₃
Molecular Weight:427.462
Hs Code.:

Synonyms:1-(4-nitro-phenyl)-2-oxo-5-(2-pyrrolidin-1-yl-ethyl)-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

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Chemical Property of 1-(4-nitro-phenyl)-2-oxo-5-(2-pyrrolidin-1-yl-ethyl)-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

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Technology Process of 1-(4-nitro-phenyl)-2-oxo-5-(2-pyrrolidin-1-yl-ethyl)-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

There total 8 articles about 1-(4-nitro-phenyl)-2-oxo-5-(2-pyrrolidin-1-yl-ethyl)-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 304465-35-8
1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

: 698396-39-3
1-(4-nitro-phenyl)-2-oxo-5-(2-pyrrolidin-1-yl-ethyl)-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); for 5h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: C₂₁H₂₂N₄O₃

: C₂₇H₂₆N₆O₄

: 105-56-6
ethyl 2-cyanoacetate

: 698396-39-3
1-(4-nitro-phenyl)-2-oxo-5-(2-pyrrolidin-1-yl-ethyl)-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

Guidance literature:: With piperidine; In ethylene glycol; at 20 ℃; for 2h;

Reference yield:

: 167954-14-5
3-[N-(4-nitrophenyl)amino]-2-formylindole

: 698396-39-3
1-(4-nitro-phenyl)-2-oxo-5-(2-pyrrolidin-1-yl-ethyl)-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / isopropyl alcohol / 2 h / Heating / reflux

2.1: ethylene glycol / 2 h / Heating / reflux

3.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C / Heating / reflux

3.2: 20 °C

With sodium hydride; triethylamine; In DMF (N,N-dimethyl-formamide); ethylene glycol; isopropyl alcohol;