(S)-tert-butyl 2-((S)-3,4-dichloro-2,5-dihydro-5-oxofuran-2-yl)-2-hydroxy-2-p-tolylacetate

Base Information

Chemical Name:(S)-tert-butyl 2-((S)-3,4-dichloro-2,5-dihydro-5-oxofuran-2-yl)-2-hydroxy-2-p-tolylacetate
CAS No.:1279018-03-9
Molecular Formula:C₁₇H₁₈Cl₂O₅
Molecular Weight:373.233
Hs Code.:

Synonyms:(S)-tert-butyl 2-((S)-3,4-dichloro-2,5-dihydro-5-oxofuran-2-yl)-2-hydroxy-2-p-tolylacetate

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Chemical Property of (S)-tert-butyl 2-((S)-3,4-dichloro-2,5-dihydro-5-oxofuran-2-yl)-2-hydroxy-2-p-tolylacetate

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Technology Process of (S)-tert-butyl 2-((S)-3,4-dichloro-2,5-dihydro-5-oxofuran-2-yl)-2-hydroxy-2-p-tolylacetate

There total 1 articles about (S)-tert-butyl 2-((S)-3,4-dichloro-2,5-dihydro-5-oxofuran-2-yl)-2-hydroxy-2-p-tolylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 75716-86-8
α-(4-methylphenyl)-α-oxoacetic acid tert-butyl ester

: 62674-12-8
3,4-dichloro-5H-furan-2-one

: 1279018-03-9
(S)-tert-butyl 2-((S)-3,4-dichloro-2,5-dihydro-5-oxofuran-2-yl)-2-hydroxy-2-p-tolylacetate

Guidance literature:: With (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(1-(diethylamino)-3-(1H-indol-3-yl)propan-2-yl)thiourea; In tetrahydrofuran; acetone; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1002/anie.201006316