3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(3-chlorophenyl)-1,2,4-oxadiazol-5(4H)-one

Base Information

• Chemical Name: 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(3-chlorophenyl)-1,2,4-oxadiazol-5(4H)-one
• CAS No.: 914471-24-2
• Molecular Formula: C₁₀H₆ClN₅O₃
• Molecular Weight: 279.642

Synonyms:3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(3-chlorophenyl)-1,2,4-oxadiazol-5(4H)-one

Chemical Property of 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(3-chlorophenyl)-1,2,4-oxadiazol-5(4H)-one

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Technology Process of 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(3-chlorophenyl)-1,2,4-oxadiazol-5(4H)-one

There total 1 articles about 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(3-chlorophenyl)-1,2,4-oxadiazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-amino-N-(3-chloro-4-fluorophenyl)-N‘-hydroxy-1,2,5-oxadiazole-3-carboximidamide (914471-09-3) + 1,1'-carbonyldiimidazole (530-62-1) → 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(3-chlorophenyl)-1,2,4-oxadiazol-5(4H)-one (914471-24-2)

Guidance literature:

In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2019.111629

Reference yield: 45.0%

3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(3-chlorophenyl)-1,2,4-oxadiazol-5(4H)-one (914471-24-2) + phenylacetyl chloride (103-80-0) → N-{4-[[(3-chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-phenylacetamide

Guidance literature:

With pyridine; dmap; for 4h;

Reference yield: 40.0%

3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(3-chlorophenyl)-1,2,4-oxadiazol-5(4H)-one (914471-24-2) → 4-(3-chlorophenyl)-3-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5(4H)-one

Guidance literature:

With dihydrogen peroxide; trifluoroacetic acid; at 45 ℃; for 12h;

upstream raw materials:

4-amino-N-(3-chloro-4-fluorophenyl)-N‘-hydroxy-1,2,5-oxadiazole-3-carboximidamide

1,1'-carbonyldiimidazole

Downstream raw materials:

N-{4-[4-(3-chlorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}-N'-phenylurea

N-{4-[4-(3-chlorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}-N,N'-diphenyldicarbonimidic diamide

tert-butyl {4-[({4-[4-(3-chlorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)carbonyl]benzyl}carbamate

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