ethyl 4-methyl-2-[3-nitro-4-(propan-2-yloxy)phenyl]-1,3-thiazole-5-carboxylate

Base Information

Chemical Name:ethyl 4-methyl-2-[3-nitro-4-(propan-2-yloxy)phenyl]-1,3-thiazole-5-carboxylate
CAS No.:144060-68-4
Molecular Formula:C₁₆H₁₈N₂O₅S
Molecular Weight:350.395
Hs Code.:

Synonyms:ethyl 4-methyl-2-[3-nitro-4-(propan-2-yloxy)phenyl]-1,3-thiazole-5-carboxylate

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Chemical Property of ethyl 4-methyl-2-[3-nitro-4-(propan-2-yloxy)phenyl]-1,3-thiazole-5-carboxylate

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Technology Process of ethyl 4-methyl-2-[3-nitro-4-(propan-2-yloxy)phenyl]-1,3-thiazole-5-carboxylate

There total 2 articles about ethyl 4-methyl-2-[3-nitro-4-(propan-2-yloxy)phenyl]-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20582-55-2
ethyl 4-methylthiazole-5-carboxylate

: 383869-57-6
4-bromo-2-nitro-1-(propan-2-yloxy)benzene

: 144060-68-4
ethyl 4-methyl-2-[3-nitro-4-(propan-2-yloxy)phenyl]-1,3-thiazole-5-carboxylate

Guidance literature:: With di-tert-butyl(cyclohexyl)phosphine; copper(I) bromide dimethylsulfide complex; potassium hydrogencarbonate; isobutyric Acid; palladium dichloride; In toluene; at 120 ℃; for 4h; Inert atmosphere;

Reference yield:

: 7693-52-9
4-bromo-2-nitrophenol

: 144060-68-4
ethyl 4-methyl-2-[3-nitro-4-(propan-2-yloxy)phenyl]-1,3-thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 110 °C / Inert atmosphere

2: isobutyric Acid; di-tert-butyl(cyclohexyl)phosphine; potassium hydrogencarbonate; palladium dichloride; copper(I) bromide dimethylsulfide complex / toluene / 4 h / 120 °C / Inert atmosphere

With di-tert-butyl(cyclohexyl)phosphine; copper(I) bromide dimethylsulfide complex; potassium carbonate; potassium hydrogencarbonate; isobutyric Acid; palladium dichloride; In N,N-dimethyl-formamide; toluene;