(R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one

Base Information

• Chemical Name: (R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one
• CAS No.: 1059188-78-1
• Molecular Formula: C₂₆H₂₃F₃N₂O₂
• Molecular Weight: 452.476

Synonyms:(R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one

Chemical Property of (R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one

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Technology Process of (R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one

There total 2 articles about (R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

→ (R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one (1059188-78-1) + (S)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one (1059188-79-2)

Guidance literature:

Reference yield: 24.0%

5-(3-methoxyphenyl)-1-(4-trifluoromethylphenyl)pyrrolidine-2,3-dione (1059188-77-0) + (R)-1-phenyl-ethyl-amine (3886-69-9) → (R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one (1059188-78-1) + (S)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one (1059188-79-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jm800416m

Reference yield: 80.0%

(R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one (1059188-78-1) → (3R,5R)-5-(3-methoxy-phenyl)-3-((R)-1-phenylethylamino)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one (1059188-74-7) + (3S,5R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-pyrrolidin-2-one (1059188-82-7)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 20 ℃; for 1h; optical yield given as %ee;

DOI:10.1021/jm800416m

upstream raw materials:

5-(3-methoxyphenyl)-1-(4-trifluoromethylphenyl)pyrrolidine-2,3-dione

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

(3R,5R)-5-(3-methoxy-phenyl)-3-((R)-1-phenylethylamino)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one

(3S,5R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)-pyrrolidin-2-one

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