(1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane

Base Information

• Chemical Name: (1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane
• CAS No.: 681425-45-6
• Molecular Formula: C₁₇H₂₄F₂N₂O₃Si
• Molecular Weight: 370.471
• Mol file: 681425-45-6.mol

Synonyms:(1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane

Chemical Property of (1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane

There total 4 articles about (1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(1α,5α,6α)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexan-1-ol (681425-44-5) + tert-butyldimethylsilyl chloride (18162-48-6) → (1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane (681425-45-6)

Guidance literature:

With 1H-imidazole; In dichloromethane; for 3h;

DOI:10.1021/jm058204j

Reference yield:

6,6-dibromo-3-azabicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester (681425-42-3) → (1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane (681425-45-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran / 0.17 h / -95 °C

1.2: catechol borane / tetrahydrofuran / 16 h / 50 °C

1.3: 15 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 18 h

2.1: 100 percent / H₂ / Pd(OH)2/C / methanol / 3 h

3.1: 0.070 g / diisopropylethylamine / dimethylformamide / 12 h / 50 °C

4.1: 88 percent / imidazole / CH₂Cl₂ / 3 h

With 1H-imidazole; n-butyllithium; hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm058204j

Reference yield:

(1α,5α,6α)-6-hydroxy-3-azabicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester (504438-12-4,1255099-53-6) → (1α,5α,6α)-6-(tert-butyldimethylsilyloxy)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane (681425-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd(OH)2/C / methanol / 3 h

2: 0.070 g / diisopropylethylamine / dimethylformamide / 12 h / 50 °C

3: 88 percent / imidazole / CH₂Cl₂ / 3 h

With 1H-imidazole; hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm058204j

upstream raw materials:

(1α,5α,6α)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexan-1-ol

tert-butyldimethylsilyl chloride

(1α,5α,6α)-3-azabicyclo[3.1.0]hexan-1-ol

6,6-dibromo-3-azabicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester

Downstream raw materials:

{4-[(1α,5α,6α)-6-(tert-butyldimethylsilanyloxy)-3-azabicyclo[3.1.0]hex-3-yl]-3,5-difluorophenyl}carbamic acid benzyl ester

4-[(1S,5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-aza-bicyclo[3.1.0]hex-3-yl]-3,5-difluoro-phenylamine