methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate

Base Information

• Chemical Name: methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate
• CAS No.: 210174-90-6
• Molecular Formula: C₂₂H₂₆O₄
• Molecular Weight: 354.446
• Mol file: 210174-90-6.mol

Synonyms:methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate

Chemical Property of methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate

There total 5 articles about methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl bromide (100-39-0) + methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate (86646-83-5) → methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate (210174-90-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

benzyl chloride (100-44-7) + methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate (86646-83-5) → methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate (210174-90-6)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 50 ℃; for 23h;

Reference yield:

trolox (56305-04-5,53188-07-1) → methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate (210174-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / diethyl ether

2: 93 percent / K₂CO₃ / acetone / 12 h / Heating

With potassium carbonate; In diethyl ether; acetone;

DOI:10.1248/cpb.48.272

upstream raw materials:

benzyl bromide

methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate

trolox

benzyl chloride

Downstream raw materials:

(6-Benzyloxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methanol

(S)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chroman-6-ol

alpha-tocotrienol

(S)-(+)-2-acetoxymethyl-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran