Technology Process of 1-(1-benzyl-2,3-dihydro-1H-inden-1-yl)-2-bromoethanone
There total 4 articles about 1-(1-benzyl-2,3-dihydro-1H-inden-1-yl)-2-bromoethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-benzyl-indan-1-carboxylic acid;
With
4-methyl-morpholine; isobutyl chloroformate;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
N-methyl-N-nitrosotoluene-p-sulfonamide;
With
potassium hydroxide;
In
diethyl ether; water;
at 20 ℃;
With
hydrogen bromide;
In
diethyl ether; water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
1.2: 1.5 h / 0 °C
2.1: water; sodium hydroxide / methanol / 1.5 h / Reflux
3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 20 °C
3.2: 20 °C
3.3: 1 h / 20 °C
With
4-methyl-morpholine; water; sodium hexamethyldisilazane; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuryl dichloride / dichloromethane / 0.58 h / 20 °C
1.2: 3 h / 20 °C
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
2.2: 1.5 h / 0 °C
3.1: water; sodium hydroxide / methanol / 1.5 h / Reflux
4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 20 °C
4.2: 20 °C
4.3: 1 h / 20 °C
With
4-methyl-morpholine; sulfuryl dichloride; water; sodium hexamethyldisilazane; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; dichloromethane;
