10.1016/j.bmcl.2008.01.055
The research focuses on the synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors. The study was conducted by a team of researchers from the Indian Institute of Chemical Technology. They prepared a series of 8-aminomethylated derivatives (1a–1j) of oroxylin A through a Mannich reaction with various primary or secondary amines and para-formaldehyde. The synthesized compounds were tested for their α-glucosidase inhibition activity against both yeast and rat intestinal α-glucosidase. The results showed that some of these derivatives exhibited significantly better α-glucosidase inhibitory activity compared to the parent compound oroxylin A. The research highlights the potential of these novel analogues in treating diseases such as type-II diabetes mellitus, cancer, and viral infections. Key chemicals involved in the research include oroxylin A, primary and secondary amines (such as morpholinyl, N-methyl piperzinyl, benzylamino, etc.), para-formaldehyde, and 2-propanol. The study also references other related compounds like baicalein and chrysin, which were identified in previous research as having biological activities.
E,
Xi,
Xn
