exo-2-trifluoroacetoxy-endo-2-(p-methylphenyl)bicyclo<2.2.1>heptan-3-one

Base Information

Chemical Name:exo-2-trifluoroacetoxy-endo-2-(p-methylphenyl)bicyclo<2.2.1>heptan-3-one
CAS No.:87518-18-1
Molecular Formula:C₁₆H₁₅F₃O₃
Molecular Weight:312.289
Hs Code.:

Synonyms:exo-2-trifluoroacetoxy-endo-2-(p-methylphenyl)bicyclo<2.2.1>heptan-3-one

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Chemical Property of exo-2-trifluoroacetoxy-endo-2-(p-methylphenyl)bicyclo<2.2.1>heptan-3-one

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Technology Process of exo-2-trifluoroacetoxy-endo-2-(p-methylphenyl)bicyclo<2.2.1>heptan-3-one

There total 11 articles about exo-2-trifluoroacetoxy-endo-2-(p-methylphenyl)bicyclo<2.2.1>heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 87518-24-9
exo-2-hydroxy-endo-2-(p-methylphenyl)bicyclo<2.2.1>heptan-3-one

: 407-25-0
trifluoroacetic anhydride

: 87518-18-1
exo-2-trifluoroacetoxy-endo-2-(p-methylphenyl)bicyclo<2.2.1>heptan-3-one

Guidance literature:: With pyridine; at 0 ℃;
DOI:10.1021/ja00362a017

Reference yield:

: 497-38-1
Norbornan-2-on

: 87518-18-1
exo-2-trifluoroacetoxy-endo-2-(p-methylphenyl)bicyclo<2.2.1>heptan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 20 percent / KNH₂, liquid NH₃ / diethyl ether / Irradiation

2: 1.) LDA / 1.) Et₂O, -78 deg C -> 40 deg C, 2.) room temperature

3: MCPBA / CH₂Cl₂ / -20 - -10 °C

4: NaOMe / methanol; H₂O / Heating

5: 95 percent / pyridine / 0 °C

With pyridine; ammonia; sodium methylate; potassium amide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja00362a017

Reference yield:

: 497-38-1
Norbornan-2-on

: 71341-38-3,87518-18-1
Trifluoro-acetic acid (1R,2S,4S)-3-oxo-2-p-tolyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 20 percent / KNH₂, liquid NH₃ / diethyl ether / Irradiation

2: 1.) LDA / 1.) Et₂O, -78 deg C -> 40 deg C, 2.) room temperature

3: MCPBA / CH₂Cl₂ / -20 - -10 °C

4: NaOMe / methanol; H₂O / Heating

5: 95 percent / pyridine / 0 °C

6: NaOAc, Ac2O / 25 °C / solvolyses of α-keto norbornyl trifluoroacetates and triflates, endo/exo rate ratio

With pyridine; ammonia; sodium methylate; sodium acetate; acetic anhydride; potassium amide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja00362a017