4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid

Base Information

• Chemical Name: 4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid
• CAS No.: 361437-12-9
• Molecular Formula: C₁₉H₁₄FNO₄
• Molecular Weight: 339.323
• Mol file: 361437-12-9.mol

Synonyms:4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid

Chemical Property of 4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid

There total 6 articles about 4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Methyl-4-methoxy-6-[4-(4-fluorophenoxy)phenyl]pyrimidine → 4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid (361437-12-9)

Guidance literature:

In pyridine;

Reference yield: 100.0%

2-[4-(4-fluorophenoxy)phenyl]-4-methoxy-6-methylpyridine (361437-11-8) → 4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid (361437-12-9)

Guidance literature:

With selenium(IV) oxide; In pyridine; for 72h; Heating;

DOI:10.1021/jm040048d

Reference yield:

4-(4-fluorophenoxy)benzonitrile (215589-24-5) → 4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid (361437-12-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 2,2,6,6-tetramethylpiperidide; lithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / -78 - -50 °C

2.1: 34 percent / POCl₃; DBU / CH₂Cl₂ / 1 h / Heating

3.1: 100 percent / methanol / 4 h / 85 °C

4.1: 100 percent / SeO₂ / pyridine / 72 h / Heating

With 2,2,6,6-tetramethyl-piperidine; selenium(IV) oxide; lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran; pyridine; methanol; dichloromethane;

DOI:10.1021/jm040048d

upstream raw materials:

2-[4-(4-fluorophenoxy)phenyl]-4-methoxy-6-methylpyridine

4-(phenylamino)pent-3-en-2-one

4-(4-fluorophenoxy)benzonitrile

4-Chloro-2-[4-(4-fluorophenoxy)phenyl]-6-methylpyridine

Downstream raw materials:

4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid methyl ester