215589-24-5

Basic information

• Product Name: 4-(4-FLUOROPHENOXY)BENZONITRILE
• Synonyms: 4-(4-FLUOROPHENOXY)BENZENECARBONITRILE;4-(4-FLUOROPHENOXY)BENZONITRILE;4-CYANO-4'-FLUORODIPHENYL ETHER;AKOS B035621;4-(4-Fluorophenoxy)
• CAS NO: 215589-24-5
• Molecular Formula: C₁₃H₈FNO
• Molecular Weight: 213.21
• Mol File: 215589-24-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 69 °C
• Boiling Point: 322.8°C at 760 mmHg
• Flash Point: 149°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.000272mmHg at 25°C
• Refractive Index: 1.591
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-(4-FLUOROPHENOXY)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-FLUOROPHENOXY)BENZONITRILE(215589-24-5)
• EPA Substance Registry System: 4-(4-FLUOROPHENOXY)BENZONITRILE(215589-24-5)

Safety Data

• Hazardous Substances Data: 215589-24-5(Hazardous Substances Data)

Usage

Uses

4-(4-fluorophenoxy)benzonitrile is a useful reactant for the preparation of 1,?2,?4-?Oxadiazol-?5-?yl benzenesulfonamides as potent and selective inhibitors of cytosolic hCA II.

InChI:InChI=1/C13H8FNO/c14-11-3-7-13(8-4-11)16-12-5-1-10(9-15)2-6-12/h1-8H

Upstream product

• 106544-66-5 2-(2,3-(methylenedioxy)-6-((trimethylsilyl)methyl)benzyl)-6,7-(methylenedioxy)-3,4-dihydroisoquinolinium perchlorate 
• 371-41-5 4-Fluorophenol 
• 1194-02-1 4-fluorobenzonitrile 
• 623-00-7 4-bromobenzenecarbonitrile 
• 116351-52-1 2,3-(methylenedioxy)-6-((trimethylsilyl)methyl)benzyl chloride 
• 106544-64-3 2,3-(methylenedioxy)-6-((trimethylsilyl)methyl)benzyl iodide 
• 106544-63-2 (2-((tert-butyldimethylsiloxy)methyl)-3,4-(methylenedioxy)benzyl)trimethylsilane 
• 58995-64-5 1-(N,N-dimethylaminomethyl)-3,4-(methylenedioxy)benzene 
• 3058-39-7 4-iodobenzonitrile 
• 352-34-1 4-fluoro-1-iodobenzene 
• 767-00-0 4-cyanophenol 
• 459-57-4 4-fluorobenzaldehyde 
• 619-72-7 4-nitrobenzonitrile 

Downstream Products

• 753500-58-2 2-[4-(4-fluorophenoxy)phenyl]-6-methyl-1H-pyridine-4-one 
• 361436-91-1 4-(4-fluorophenoxy)benzamidine acetate 
• 606129-90-2 3,6-di(N-carbazolyl)carbazole 
• 1443126-37-1 5-[4-(4-fluorophenoxy)phenyl]-N,N-dimethyl-2H-tetrazole-2-carboxamide 
• 1443126-23-5 5-(4-(4-fluorophenoxy)phenyl)-1H-tetrazole 
• 299206-79-4 2-[4-(4-Fluorophenoxy)phenyl]-1H-imidazole 
• 215589-52-9 N-<4-(4-fluorophenoxy)benzyl>tetrahydropyran-4-ylamine 
• 501667-16-9 6-[4-(4-fluoro-phenoxy)-phenyl]-4-morpholin-4-yl-pyridine-2-carboxylic acid methyl ester 
• 501667-14-7 4-{2-[4-(4-fluorophenoxy)phenyl]-6-methyl-pyridine-4-yl}morpholine 

Relevant articles and documents

COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME

The present invention provides a compound represented by chemical formula 1 and an organic light emitting device comprising the same. The organic light emitting device including the compound has excellent electrochemical and thermal stability, and thus has excellent lifespan characteristics.

Synthesis of copper nanoparticles supported on a microporous covalent triazine polymer: An efficient and reusable catalyst for O-arylation reaction

Copper nanoparticles were supported on a microporous covalent triazine polymer prepared by the Friedel-Crafts reaction (Cu@MCTP-1). The resulting material was characterized by powder X-ray diffraction, thermogravimetric analysis, N2 adsorption-desorption isotherms at 77 K, transmission electron microscopy, X-ray photoelectron spectroscopy, and inductively coupled plasma optical emission spectroscopy, and Cu particles with an average size of 3.0 nm and a BET total surface area of ca. 1002 m2 g-1 were obtained. Cu@MCTP-1 was evaluated as a heterogeneous catalyst for the Ullmann coupling of O-arylation over a series of aryl halides and phenols without employing expensive ligands or inert atmosphere, which produced an excellent yield of the corresponding diaryl ethers. The catalyst could be recovered by simple centrifugation and was reusable at least five times with only a slight decrease in catalytic activity.

Structure-activity relationship for the oxadiazole class of antibiotics

The structure-activity relationship (SAR) for the newly discovered oxadiazole class of antibiotics is described with evaluation of 120 derivatives of the lead structure. This class of antibiotics was discovered by in silico docking and scoring against the crystal structure of a penicillin-binding protein. They impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacterium Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) and vancomycin-resistant and linezolid-resistant S. aureus. 5-(1H-Indol-5-yl)-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazole (antibiotic 75b) was efficacious in a mouse model of MRSA infection, exhibiting a long half-life, a high volume of distribution, and low clearance. This antibiotic is bactericidal and is orally bioavailable in mice. This class of antibiotics holds great promise in recourse against infections by MRSA.