(1S,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol

Base Information

Chemical Name:(1S,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol
CAS No.:115243-98-6
Molecular Formula:C₂₆H₂₉NO₆S
Molecular Weight:483.585
Hs Code.:

Synonyms:(1S,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol

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Chemical Property of (1S,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol

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Technology Process of (1S,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol

There total 6 articles about (1S,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118319-78-1
(S)-2-Benzyloxy-2-((3aR,5S,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanone

: 115243-98-6
(1S,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol

: 115243-99-7
(1R,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol

Guidance literature:: With potassium tri-sec-butyl-borohydride; In tetrahydrofuran; at -78 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00264a036

Reference yield:

: 100-39-0
benzyl bromide

: 115243-98-6
(1S,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: NaH, n-tetrabutylammonium iodide / tetrahydrofuran / Ambient temperature

3: 2.) n-tetrabutylammonium fluoride / 1.) CH₂Cl₂, room temp., overnight 2.) THF, 1-2 h

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)81646-X

Reference yield:

: 115243-97-5
(5S)-1,2-O-isopropylidene-3-O-benzyl-5-(2-thiazolyl)-α-D-xylo-pentofuranose

: 115243-98-6
(1S,2R)-2-Benzyloxy-2-((3aR,5R,6S,6aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-thiazol-2-yl-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: NaH, n-tetrabutylammonium iodide / tetrahydrofuran / Ambient temperature

3: 2.) n-tetrabutylammonium fluoride / 1.) CH₂Cl₂, room temp., overnight 2.) THF, 1-2 h

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)81646-X