Technology Process of C54H69N9O12
There total 11 articles about C54H69N9O12 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 1h;
Molecular sieve;
DOI:10.1021/ol4002762
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 3102.97 Torr
2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere
2.2: 8 h / Inert atmosphere; Reflux
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Molecular sieve
With
palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol4002762
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere
1.2: 8 h / Inert atmosphere; Reflux
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Molecular sieve
With
chloroformic acid ethyl ester; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol4002762
