Malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester

Base Information

• Chemical Name: Malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester
• CAS No.: 122663-98-3
• Molecular Formula: C₂₀H₂₈O₄S
• Molecular Weight: 364.506
• Mol file: 122663-98-3.mol

Synonyms:Malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester

Chemical Property of Malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of Malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester

There total 3 articles about Malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Malonic acid ethyl ester 1-(3-phenylsulfanyl-prop-1-ynyl)-hexyl ester (122663-95-0) → Malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester (122663-98-3)

Guidance literature:

With hydrogen; palladium on barium sulfate; In methanol;

DOI:10.1016/S0040-4039(00)99523-6

Reference yield:

phenyl propargyl sulfide (5651-88-7) → Malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester (122663-98-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) ethylmagnesium bromide / 2.) THF, 0 deg C

2: 80 percent / pyridine / tetrahydrofuran / 3 h / 0 °C

3: 82 percent / H₂ / 5percent Pd-BaSO₄ / methanol

With pyridine; ethylmagnesium bromide; hydrogen; palladium on barium sulfate; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4039(00)99523-6

Reference yield:

1-Phenylsulfanyl-non-2-yn-4-ol (122663-91-6) → Malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester (122663-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine / tetrahydrofuran / 3 h / 0 °C

2: 82 percent / H₂ / 5percent Pd-BaSO₄ / methanol

With pyridine; hydrogen; palladium on barium sulfate; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4039(00)99523-6

upstream raw materials:

Malonic acid ethyl ester 1-(3-phenylsulfanyl-prop-1-ynyl)-hexyl ester

phenyl propargyl sulfide

1-Phenylsulfanyl-non-2-yn-4-ol

Downstream raw materials:

(3S,4R,5R)-2-Oxo-5-pentyl-3-phenylsulfanyl-4-vinyl-tetrahydro-furan-3-carboxylic acid ethyl ester

2-Diazo-malonic acid ethyl ester 1-((Z)-3-phenylsulfanyl-propenyl)-hexyl ester