diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate

Base Information

Chemical Name:diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate
CAS No.:1168133-61-6
Molecular Formula:C₁₇H₂₁F₂NO₆
Molecular Weight:373.354
Hs Code.:

Synonyms:diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate

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Chemical Property of diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate

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Technology Process of diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate

There total 1 articles about diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 10203-58-4
(2-methylpropyl)-propanedioic acid, diethyl ester

: 2105-61-5
1,2,4-trifluoro-5-nitrobenzene

: 1168133-61-6
diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate

Guidance literature:: (2-methylpropyl)-propanedioic acid, diethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 0.833333h; Inert atmosphere;

1,2,4-trifluoro-5-nitrobenzene; In N,N-dimethyl-formamide; at 0 - 25 ℃;

Reference yield: 72.0%

: 1168133-61-6
diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate

: 1168133-63-8
2-(2,5-difluoro-4-nitrophenyl)-4-methylpentanoic acid

Guidance literature:: With ethanol; water; acetic acid; for 96h; Heating; Reflux;

Reference yield:

: 1168133-61-6
diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate

: 1168133-62-7
2-(2,5-difluoro-4-nitrophenyl)-4-methylpentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / water; ethanol / 96 h / Reflux

2: sulfuric acid / 3 h / Reflux

With sulfuric acid; acetic acid; In ethanol; water;