2-(5-cyclopropylmethoxy-2-fluoro-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester

Base Information

Chemical Name:2-(5-cyclopropylmethoxy-2-fluoro-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester
CAS No.:1168133-64-9
Molecular Formula:C₂₀H₂₆FNO₅
Molecular Weight:379.429
Hs Code.:

Synonyms:2-(5-cyclopropylmethoxy-2-fluoro-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester

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Chemical Property of 2-(5-cyclopropylmethoxy-2-fluoro-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester

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Technology Process of 2-(5-cyclopropylmethoxy-2-fluoro-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester

There total 5 articles about 2-(5-cyclopropylmethoxy-2-fluoro-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 2516-33-8
Cyclopropylmethanol

: 1168133-62-7
2-(2,5-difluoro-4-nitrophenyl)-4-methylpentanoic acid ethyl ester

: 1168133-64-9
2-(5-cyclopropylmethoxy-2-fluoro-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester

Guidance literature:: Cyclopropylmethanol; With n-butyllithium; In hexane; at -15 - 25 ℃; Inert atmosphere;

2-(2,5-difluoro-4-nitrophenyl)-4-methylpentanoic acid ethyl ester; In hexane; at 25 ℃;

Reference yield:

: 10203-58-4
(2-methylpropyl)-propanedioic acid, diethyl ester

: 1168133-64-9
2-(5-cyclopropylmethoxy-2-fluoro-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.83 h / 0 - 20 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: acetic acid / water; ethanol / 96 h / Reflux

3.1: sulfuric acid / 3 h / Reflux

4.1: n-butyllithium / hexane / 1 h / -15 - 25 °C / Inert atmosphere

4.2: 16 h / 25 °C

With n-butyllithium; sulfuric acid; sodium hydride; acetic acid; In ethanol; hexane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1168133-61-6
diethyl 2-(2,5-difluoro-4-nitrophenyl)-2-isobutylmalonate

: 1168133-64-9
2-(5-cyclopropylmethoxy-2-fluoro-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / water; ethanol / 96 h / Reflux

2.1: sulfuric acid / 3 h / Reflux

3.1: n-butyllithium / hexane / 1 h / -15 - 25 °C / Inert atmosphere

3.2: 16 h / 25 °C

With n-butyllithium; sulfuric acid; acetic acid; In ethanol; hexane; water;