2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester

Base Information

• Chemical Name: 2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester
• CAS No.: 271578-69-9
• Molecular Formula: C₂₆H₄₄O₆Si
• Molecular Weight: 480.717

Synonyms:2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester

Chemical Property of 2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester

There total 11 articles about 2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 2,2-Dimethyl-propionic acid (E)-4-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-phenyl)-but-2-enyl ester (351379-98-1) → 2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester (271578-69-9)

Guidance literature:

With 1H-imidazole; dmap; In dichloromethane; for 1h;

DOI:10.1016/S0040-4039(00)00105-2

Reference yield:

2-hydroxy-4-methoxy-3-methylbenzaldehyde (54700-36-6) → 2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester (271578-69-9)

Guidance literature:

Multi-step reaction with 11 steps

1: 100 percent / K₂CO₃ / acetonitrile / 5 h / Heating

2: 85 percent / H₂O₂; SeO₂; water / 2-methyl-propan-2-ol / 5 h / 40 °C

3: 100 percent / (i-Pr)2NEt / CH₂Cl₂ / 12 h / 80 °C

4: 96 percent / Me₂NPh / toluene / 12 h / 210 °C

5: 87 percent / K₂CO₃ / acetonitrile / 12 h / Heating

6: TBAF / tetrahydrofuran / 1 h

7: pyridine / CH₂Cl₂ / 3 h

8: HCl; H₂O / tetrahydrofuran; propan-2-ol / 12 h

9: 96 percent / Et₂AlCl / CH₂Cl₂ / 12 h

10: 90 percent / K₂CO₃ / CHCl₃; methanol / 12 h / Heating

11: 99 percent / imidazole; DMAP / CH₂Cl₂ / 1 h

With pyridine; 1H-imidazole; hydrogenchloride; dmap; selenium(IV) oxide; tetrabutyl ammonium fluoride; water; dihydrogen peroxide; diethylaluminium chloride; potassium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; isopropyl alcohol; toluene; acetonitrile; tert-butyl alcohol; 1: Etherification / 2: oxidative cleavage / 3: Etherification / 4: p-Claisen rearrangement / 5: Etherification / 6: deprotection / 7: Acylation / 8: Hydrolysis / 9: hydroxymethylation / 10: Etherification / 11: Etherification;

DOI:10.1016/S0040-4039(00)00105-2

Reference yield:

(E)-4-(2,4-Dimethoxy-5-methoxymethoxy-3-methyl-phenyl)-but-2-en-1-ol → 2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester (271578-69-9)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / CH₂Cl₂ / 3 h

2: HCl; H₂O / tetrahydrofuran; propan-2-ol / 12 h

3: 96 percent / Et₂AlCl / CH₂Cl₂ / 12 h

4: 90 percent / K₂CO₃ / CHCl₃; methanol / 12 h / Heating

5: 99 percent / imidazole; DMAP / CH₂Cl₂ / 1 h

With pyridine; 1H-imidazole; hydrogenchloride; dmap; water; diethylaluminium chloride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; chloroform; isopropyl alcohol; 1: Acylation / 2: Hydrolysis / 3: hydroxymethylation / 4: Etherification / 5: Etherification;

DOI:10.1016/S0040-4039(00)00105-2

upstream raw materials:

tert-butyldimethylsilyl chloride

2,2-Dimethyl-propionic acid (E)-4-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-phenyl)-but-2-enyl ester

2-hydroxy-4-methoxy-3-methylbenzaldehyde

2-[4-(tert-butyl-dimethyl-silanyloxy)-but-2-enyloxy]-4-methoxy-3-methyl-phenol

Downstream raw materials:

4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-en-1-ol

{2-[(S)-2-Azido-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-3,5,6-trimethoxy-4-methyl-benzyloxy}-tert-butyl-dimethyl-silane

(2S,3S)-3-Azido-4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-butane-1,2-diol

2-(tert-butoxycarbonyl-methyl-amino)-3-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-propionic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 271578-69-9 2,2-dimethyl-propionic acid 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-enyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send