Benzyl-((3aR,7aR)-1,3-dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-methyl-amine

Base Information

• Chemical Name: Benzyl-((3aR,7aR)-1,3-dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-methyl-amine
• CAS No.: 197240-64-5
• Molecular Formula: C₁₆H₂₆N₃OP
• Molecular Weight: 307.376

Synonyms:Benzyl-((3aR,7aR)-1,3-dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-methyl-amine

Chemical Property of Benzyl-((3aR,7aR)-1,3-dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-methyl-amine

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Technology Process of Benzyl-((3aR,7aR)-1,3-dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-methyl-amine

There total 1 articles about Benzyl-((3aR,7aR)-1,3-dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-methyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(3aR,7aR)-2-chloro-1,3-dimethyloctahydro-1H-1,3,2-benzodiazaphosphole 2-oxide (137943-77-2) + benzyl-methyl-amine (103-67-3) → Benzyl-((3aR,7aR)-1,3-dimethyl-2-oxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl)-methyl-amine (197240-64-5)

Guidance literature:

With triethylamine; In toluene; for 18h; Heating;

DOI:10.1055/s-1997-1526

Reference yield:

benzyl bromide (100-39-0) + Benzyl-((3aR,7aR)-1,3-dimethyl-2-oxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl)-methyl-amine (197240-64-5) → ((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl)-((R)-1,2-diphenyl-ethyl)-methyl-amine + ((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl)-((S)-1,2-diphenyl-ethyl)-methyl-amine

Guidance literature:

With n-butyllithium; Yield given; 1.) THF, n-hexane, -78 deg C, 1 h; 2.) THF, -78 deg C, 30 min;

DOI:10.1055/s-1997-1526

upstream raw materials:

(3aR,7aR)-2-chloro-1,3-dimethyloctahydro-1H-1,3,2-benzodiazaphosphole 2-oxide

benzyl-methyl-amine

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