12b-hydroxy-2,3-dimethoxy-5,12b-dihydro-6H-isoindolo[1,2-a]isoquinolin-8-one

Base Information

Chemical Name:12b-hydroxy-2,3-dimethoxy-5,12b-dihydro-6H-isoindolo[1,2-a]isoquinolin-8-one
CAS No.:188064-71-3
Molecular Formula:C₁₈H₁₇NO₄
Molecular Weight:311.337
Hs Code.:

Synonyms:12b-hydroxy-2,3-dimethoxy-5,12b-dihydro-6H-isoindolo[1,2-a]isoquinolin-8-one

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Chemical Property of 12b-hydroxy-2,3-dimethoxy-5,12b-dihydro-6H-isoindolo[1,2-a]isoquinolin-8-one

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Technology Process of 12b-hydroxy-2,3-dimethoxy-5,12b-dihydro-6H-isoindolo[1,2-a]isoquinolin-8-one

There total 5 articles about 12b-hydroxy-2,3-dimethoxy-5,12b-dihydro-6H-isoindolo[1,2-a]isoquinolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 493-49-2
6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

: 188064-71-3
12b-hydroxy-2,3-dimethoxy-5,12b-dihydro-6H-isoindolo[1,2-a]isoquinolin-8-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

1.2: 80 percent / tetrahydrofuran; hexane / 2.17 h / -78 - 20 °C

2.1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C

With n-butyllithium; tert.-butyl lithium; In tetrahydrofuran; hexane; pentane;
DOI:10.1002/ejoc.200500312

Reference yield:

: 85-44-9
phthalic anhydride

: 188064-71-3
12b-hydroxy-2,3-dimethoxy-5,12b-dihydro-6H-isoindolo[1,2-a]isoquinolin-8-one

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / acetic acid / Heating

2: 95 percent / ICl / acetic acid / 2 h / 20 °C

3: 96 percent / n-BuLi / tetrahydrofuran; hexane / 4 h / -78 °C

With n-butyllithium; Iodine monochloride; In tetrahydrofuran; hexane; acetic acid;
DOI:10.1021/jo962155o

Reference yield:

: 85-44-9
phthalic anhydride

: 188064-71-3
12b-hydroxy-2,3-dimethoxy-5,12b-dihydro-6H-isoindolo[1,2-a]isoquinolin-8-one

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / Reflux

2: trifluorormethanesulfonic acid / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

With trifluorormethanesulfonic acid; In dichloromethane; toluene;
DOI:10.1039/c1ob06349a