3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester

Base Information

• Chemical Name: 3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester
• CAS No.: 213740-69-3
• Molecular Formula: C₂₄H₄₀N₄O₁₀S₂
• Molecular Weight: 608.734
• Mol file: 213740-69-3.mol

Synonyms:3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester

Chemical Property of 3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester

There total 1 articles about 3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

?tert-butyl [2-(chlorosulfonyl)ethyl]carbamate (134019-73-1) + 3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid methyl ester (213740-68-2) → 3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester (213740-69-3)

Guidance literature:

With 4-methyl-morpholine; hydrogenchloride; Yield given. Multistep reaction; 1.) Et₂O, 2.) CH₂Cl₂;

DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1846::AID-ANIE1846>3.0.CO;2-E

Reference yield:

3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester (213740-69-3) → 3,5-Bis-{[2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propane-1-sulfonylamino)-ethanesulfonylamino]-methyl}-benzoic acid 2-{ethyl-[4-(4-nitro-phenylazo)-phenyl]-amino}-ethyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) HCl, 2.) N-methylmorpholine / 1.) Et₂O, 2.) CH₂Cl₂

2: 95 percent / NaOH / methanol; dioxane

3: 41 percent / diisopropylcarbodiimide, DMAP

With 4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; diisopropyl-carbodiimide; In 1,4-dioxane; methanol;

DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1846::AID-ANIE1846>3.0.CO;2-E

Reference yield:

3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester (213740-69-3) → 3,5-Bis-{[2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propane-1-sulfonylamino)-ethanesulfonylamino]-methyl}-benzoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) HCl, 2.) N-methylmorpholine / 1.) Et₂O, 2.) CH₂Cl₂

2: 95 percent / NaOH / methanol; dioxane

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; In 1,4-dioxane; methanol;

DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1846::AID-ANIE1846>3.0.CO;2-E

upstream raw materials:

?tert-butyl [2-(chlorosulfonyl)ethyl]carbamate

3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid methyl ester

Downstream raw materials:

3,5-Bis-{[2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propane-1-sulfonylamino)-ethanesulfonylamino]-methyl}-benzoic acid methyl ester