213740-68-2Relevant academic research and scientific papers
Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part
Loewik, Dennis W. P. M.,Weingarten, W. David,Broekema, Matthias,Brouwer, Arwin J.,Still, W. Clark,Liskamp, Rob M. J.
, p. 1846 - 1850 (2007/10/03)
With preservation of selectivity, the hinge part of tweezerlike synthetic receptor molecules can be varied to achieve a higher affinity. The synthetic peptidosulfonamide receptor (below left; R = Disperse Red 1) with the bis(aminomethyl)benzoic acid hinge selectively bound the tripeptide shown below on the right (K(a) = 4100 M-1). Combination of a diversity in the hinge part with that present in the tweezer arms will provide access to large and diverse synthetic receptor libraries.
