Technology Process of 5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-7-methyl-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine
There total 4 articles about 5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-7-methyl-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
formaldehyd; 5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine;
In
methanol; water;
at 20 ℃;
for 1h;
With
sodium cyanoborohydride; acetic acid;
In
methanol; water;
at 20 ℃;
for 2h;
With
ammonium hydroxide;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 5 h / 90 °C
2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / isopropyl alcohol; methanol / 50 °C / Inert atmosphere
3.1: water; methanol / 1 h / 20 °C
3.2: 2 h / 20 °C
With
hydrogenchloride; hydrogen; caesium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
methanol; 1,2-dimethoxyethane; water; isopropyl alcohol;
1.1: Suzuki-Miyaura Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / isopropyl alcohol; methanol / 50 °C / Inert atmosphere
2.1: water; methanol / 1 h / 20 °C
2.2: 2 h / 20 °C
With
hydrogenchloride; hydrogen;
palladium 10% on activated carbon;
In
methanol; water; isopropyl alcohol;
