2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-phenylpyrrole-2-carboxylate

Base Information

Chemical Name:2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-phenylpyrrole-2-carboxylate
CAS No.:252861-21-5
Molecular Formula:C₂₅H₁₉Br₂NO₂
Molecular Weight:525.239
Hs Code.:

Synonyms:2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-phenylpyrrole-2-carboxylate

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Chemical Property of 2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-phenylpyrrole-2-carboxylate

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Technology Process of 2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-phenylpyrrole-2-carboxylate

There total 9 articles about 2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-phenylpyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 28557-00-8
phenylzinc chloride

: 252861-23-7
2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-iodopyrrole-2-carboxylate

: 252861-21-5
2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-phenylpyrrole-2-carboxylate

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; various solvents; N,N-dimethyl-formamide; at 18 ℃; for 1h;
DOI:10.1071/CH99021

Reference yield: 95.0%

: 252861-21-5
2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-phenylpyrrole-2-carboxylate

Guidance literature:

Reference yield:

: 35302-72-8
pyrrol-2-yl trichloromethyl ketone

: 252861-21-5
2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-phenylpyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / I₂; AgOCOCF₃ / CHCl₃ / 2 h / 18 °C

2: 92 percent / aq. K₂CO₃ / dimethylsulfoxide / 3 h / 18 °C

3: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 18 °C

4: NEt₃; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h

5: 89 percent / K₂CO₃; Et₄NCl / dimethylformamide / 2 h / 80 °C

6: 95 percent / PdCl₂(PPh₃)2 / dimethylformamide; tetrahydrofuran; various solvents / 1 h / 18 °C

With dmap; oxalyl dichloride; tetraethylammonium chloride; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; chloroform; various solvents; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Iodination / 2: Hydrolysis / 3: Substitution / 4: Esterification / 5: Alkylation / 6: Negishi cross-coupling;
DOI:10.1071/CH99021