2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester

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Chemical Name:2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester
CAS No.:677707-87-8
Molecular Formula:C₅₃H₈₆O₉Si₂
Molecular Weight:923.431
Hs Code.:

2-[6-(2-benzyloxy-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4<i>H</i>-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester

Synonyms:2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of 2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of 2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester

There total 40 articles about 2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-hept-6-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester

: 677707-87-8
2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With sodium acetate; toluene-4-sulfonic acid hydrazide; In 1,2-dimethoxyethane; for 4h; Heating;
DOI:10.1021/jo0507993

Reference yield:

: 154714-19-9
5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 677707-87-8
2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / pyridine / 12 h / 0 °C

2.1: K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran / 24 h / 60 °C

2.2: 70 percent / NaOH; H₂O₂ / tetrahydrofuran

3.1: 99 percent / hydrogen / Pd/C / methanol / 6 h / 20 °C

4.1: 98 percent / triethylamine; sulfur trioxide; pyridine / dimethylsulfoxide; CH₂Cl₂ / 5 h / 0 - 20 °C

5.1: NaHMDS / diethyl ether / 0.25 h / -78 °C

5.2: 83 percent / diethyl ether / 15 h / 20 °C

6.1: 94 percent / p-toluenesulfonyl hydrazide; NaOAc / 1,2-dimethoxy-ethane / 4 h / Heating

With pyridine; potassium phosphate; sulfur trioxide; hydrogen; sodium acetate; sodium hexamethyldisilazane; triethylamine; toluene-4-sulfonic acid hydrazide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; dimethyl sulfoxide; 2.1: Suzuki reaction;
DOI:10.1021/jo0507993

Reference yield:

: 863660-01-9
((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde

: 677707-87-8
2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / LiI; CrCl₂ / tetrahydrofuran / 16 h / 20 °C

2.1: K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran / 24 h / 60 °C

2.2: 70 percent / NaOH; H₂O₂ / tetrahydrofuran

3.1: 99 percent / hydrogen / Pd/C / methanol / 6 h / 20 °C

4.1: 98 percent / triethylamine; sulfur trioxide; pyridine / dimethylsulfoxide; CH₂Cl₂ / 5 h / 0 - 20 °C

5.1: NaHMDS / diethyl ether / 0.25 h / -78 °C

5.2: 83 percent / diethyl ether / 15 h / 20 °C

6.1: 94 percent / p-toluenesulfonyl hydrazide; NaOAc / 1,2-dimethoxy-ethane / 4 h / Heating

With pyridine; chromium dichloride; potassium phosphate; sulfur trioxide; hydrogen; sodium acetate; sodium hexamethyldisilazane; triethylamine; toluene-4-sulfonic acid hydrazide; lithium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; dimethyl sulfoxide; 2.1: Suzuki reaction;
DOI:10.1021/jo0507993