(3S,3'S)-2,2'-(propane-1,3-diyl)bis(N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)

Base Information

Chemical Name:(3S,3'S)-2,2'-(propane-1,3-diyl)bis(N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)
CAS No.:1383448-94-9
Molecular Formula:C₃₅H₃₆N₄O₂
Molecular Weight:544.696
Hs Code.:

Synonyms:(3S,3'S)-2,2'-(propane-1,3-diyl)bis(N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)

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Chemical Property of (3S,3'S)-2,2'-(propane-1,3-diyl)bis(N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)

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Technology Process of (3S,3'S)-2,2'-(propane-1,3-diyl)bis(N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)

There total 3 articles about (3S,3'S)-2,2'-(propane-1,3-diyl)bis(N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 109-64-8
1,3-dibromo-propane

: 501355-25-5,736900-25-7
(S)-N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

: 1383448-94-9
(3S,3'S)-2,2'-(propane-1,3-diyl)bis(N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)

Guidance literature:: With potassium carbonate; In acetonitrile; for 12h; Microwave irradiation;
DOI:10.1016/j.tetasy.2012.04.010

Reference yield:

: C₂₁H₂₁NO₆

: 1383448-94-9
(3S,3'S)-2,2'-(propane-1,3-diyl)bis(N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 18 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

3: potassium carbonate / acetonitrile / 12 h / Microwave irradiation

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tetasy.2012.04.010

Reference yield:

: 79261-58-8
(S)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester

: 1383448-94-9
(3S,3'S)-2,2'-(propane-1,3-diyl)bis(N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: dichloromethane / 18 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

4: potassium carbonate / acetonitrile / 12 h / Microwave irradiation

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tetasy.2012.04.010