N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide

Base Information

• Chemical Name: N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide
• CAS No.: 1607830-06-7
• Molecular Formula: C₃₀H₃₇BrN₂O₄S₂
• Molecular Weight: 633.671
• Mol file: 1607830-06-7.mol

Synonyms:N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide

Chemical Property of N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide

There total 5 articles about N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-(3-bromobut-3-en-1-yl)-4-methylbenzenesulfonamide (1361583-02-9) + C19H24BrNO2S (1607830-18-1) → N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide (1607830-06-7)

Guidance literature:

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; In toluene; at 80 ℃; for 2.5h; Inert atmosphere;

DOI:10.1039/c3cc45634j

Reference yield:

N-(tert-butoxycarbonyl)-N-but-3-ynyl-4-methylbenzenesulfonamide (338463-00-6) → N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide (1607830-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 4.5 h / -78 - 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: potassium phosphate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 2.5 h / 80 °C / Inert atmosphere

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; boron tribromide; In dichloromethane; toluene;

DOI:10.1039/c3cc45634j

Reference yield:

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide (18303-04-3) → N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide (1607830-06-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 4.5 h / -78 - 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: potassium phosphate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 2.5 h / 80 °C / Inert atmosphere

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene; 1.1: |Mitsunobu Displacement;

DOI:10.1039/c3cc45634j

upstream raw materials:

N-(tert-butoxycarbonyl)-N-but-3-ynyl-4-methylbenzenesulfonamide

tert-butyl (4-bromobut-3-yn-1-yl)(tosyl)carbamate

N-(4-bromobut-3-yn-1-yl)-4-methylbenzenesulfonamide

N-(3-bromobut-3-en-1-yl)-4-methylbenzenesulfonamide

Downstream raw materials:

5-hexyl-1,6-ditosyl-1,2,3,6,7,8-hexahydropyrrolo[2,3-e]indole