tert-butyl [(2R)-2-[6-(acetylamino)-3-pyridinyl]-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl][2-(4-iodophenoxy)ethyl]carbamate

Base Information

• Chemical Name: tert-butyl [(2R)-2-[6-(acetylamino)-3-pyridinyl]-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl][2-(4-iodophenoxy)ethyl]carbamate
• CAS No.: 945549-00-8
• Molecular Formula: C₂₈H₄₂IN₃O₅Si
• Molecular Weight: 655.649
• Mol file: 945549-00-8.mol

Synonyms:tert-butyl [(2R)-2-[6-(acetylamino)-3-pyridinyl]-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl][2-(4-iodophenoxy)ethyl]carbamate

Chemical Property of tert-butyl [(2R)-2-[6-(acetylamino)-3-pyridinyl]-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl][2-(4-iodophenoxy)ethyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [(2R)-2-[6-(acetylamino)-3-pyridinyl]-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl][2-(4-iodophenoxy)ethyl]carbamate

There total 1 articles about tert-butyl [(2R)-2-[6-(acetylamino)-3-pyridinyl]-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl][2-(4-iodophenoxy)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H34IN3O3Si (945548-98-1) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl [(2R)-2-[6-(acetylamino)-3-pyridinyl]-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl][2-(4-iodophenoxy)ethyl]carbamate (945549-00-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm8000345

Reference yield:

[3-isobutyl-4-(methoxycarbonyl)phenyl]boronic acid (855482-81-4) + tert-butyl [(2R)-2-[6-(acetylamino)-3-pyridinyl]-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl][2-(4-iodophenoxy)ethyl]carbamate (945549-00-8) → C40H57N3O7Si (945548-96-9)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; sodium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm8000345

upstream raw materials:

C₂₃H₃₄IN₃O₃Si

di-tert-butyl dicarbonate

Downstream raw materials:

C₄₀H₅₇N₃O₇Si