3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Base Information

Chemical Name:3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
CAS No.:1262106-52-4
Molecular Formula:C₂₄H₂₁F₃N₄O₃
Molecular Weight:470.451
Hs Code.:

Synonyms:3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

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Chemical Property of 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

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Technology Process of 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

There total 3 articles about 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262107-18-5
2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

: 1262106-52-4
3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: 2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole; With sodium azide; In dimethyl sulfoxide; at 70 ℃; for 15.5h;

With triphenylphosphine; In tetrahydrofuran; water; at 60 ℃; for 2h;

With acetic acid; at 130 ℃; for 2h;

Reference yield:

: 220239-67-8
2-[2-(trifluoromethoxy)phenyl]acetic acid

: 1262106-52-4
3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

1.2: 16 h / 20 °C

2.1: triethylamine; diethyl dicarbonate / N,N-dimethyl-formamide / 17 h / 20 °C

2.2: 2 h / 80 °C

3.1: sodium azide / dimethyl sulfoxide / 15.5 h / 70 °C

3.2: 2 h / 60 °C

3.3: 2 h / 130 °C

With n-butyllithium; sodium azide; triethylamine; diethyl dicarbonate; In tetrahydrofuran; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1262107-19-6
5-chloro-2-[2-(trifluoromethoxy)phenyl]pentanoic acid

: 1262106-52-4
3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; diethyl dicarbonate / N,N-dimethyl-formamide / 17 h / 20 °C

1.2: 2 h / 80 °C

2.1: sodium azide / dimethyl sulfoxide / 15.5 h / 70 °C

2.2: 2 h / 60 °C

2.3: 2 h / 130 °C

With sodium azide; triethylamine; diethyl dicarbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;