2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Base Information

Chemical Name:2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole
CAS No.:1262107-18-5
Molecular Formula:C₂₄H₂₁ClF₃N₃O₄
Molecular Weight:507.897
Hs Code.:

Synonyms:2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

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Chemical Property of 2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

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Technology Process of 2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

There total 2 articles about 2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1262107-19-6
5-chloro-2-[2-(trifluoromethoxy)phenyl]pentanoic acid

: 1262106-83-1
3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride

: 1262107-18-5
2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: 5-chloro-2-[2-(trifluoromethoxy)phenyl]pentanoic acid; 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride; With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

With tetrachloromethane; triphenylphosphine; In acetonitrile; at 80 ℃; for 2h;

Reference yield:

: 220239-67-8
2-[2-(trifluoromethoxy)phenyl]acetic acid

: 1262107-18-5
2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

1.2: 16 h / 20 °C

2.1: triethylamine; diethyl dicarbonate / N,N-dimethyl-formamide / 17 h / 20 °C

2.2: 2 h / 80 °C

With n-butyllithium; triethylamine; diethyl dicarbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1262107-18-5
2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

: 1262106-52-4
3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: 2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole; With sodium azide; In dimethyl sulfoxide; at 70 ℃; for 15.5h;

With triphenylphosphine; In tetrahydrofuran; water; at 60 ℃; for 2h;

With acetic acid; at 130 ℃; for 2h;