(2E)-3-[4-[3-[2-[morpholin-4-yl]ethyl]-1H-indol-1-yl]phenyl]-N-[pyridin-3-ylmethyl]prop-2-enamide

Base Information

Chemical Name:(2E)-3-[4-[3-[2-[morpholin-4-yl]ethyl]-1H-indol-1-yl]phenyl]-N-[pyridin-3-ylmethyl]prop-2-enamide
CAS No.:1416891-66-1
Molecular Formula:C₂₉H₃₀N₄O₂
Molecular Weight:466.583
Hs Code.:

Synonyms:(2E)-3-[4-[3-[2-[morpholin-4-yl]ethyl]-1H-indol-1-yl]phenyl]-N-[pyridin-3-ylmethyl]prop-2-enamide

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Chemical Property of (2E)-3-[4-[3-[2-[morpholin-4-yl]ethyl]-1H-indol-1-yl]phenyl]-N-[pyridin-3-ylmethyl]prop-2-enamide

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Technology Process of (2E)-3-[4-[3-[2-[morpholin-4-yl]ethyl]-1H-indol-1-yl]phenyl]-N-[pyridin-3-ylmethyl]prop-2-enamide

There total 6 articles about (2E)-3-[4-[3-[2-[morpholin-4-yl]ethyl]-1H-indol-1-yl]phenyl]-N-[pyridin-3-ylmethyl]prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3731-52-0
3-Aminomethylpyridine

: 1416892-58-4
C₂₃H₂₄N₂O₃

: 1416891-66-1
(2E)-3-[4-[3-[2-[morpholin-4-yl]ethyl]-1H-indol-1-yl]phenyl]-N-[pyridin-3-ylmethyl]prop-2-enamide

Guidance literature:: C₂₃H₂₄N₂O₃; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

3-Aminomethylpyridine; In N,N-dimethyl-formamide; for 4h;

Reference yield:

: 3389-21-7
3-(2-bromoethyl)-1H-indole

: 1416891-66-1
(2E)-3-[4-[3-[2-[morpholin-4-yl]ethyl]-1H-indol-1-yl]phenyl]-N-[pyridin-3-ylmethyl]prop-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 °C

2.1: potassium phosphate; copper(l) iodide; trans-1,2-cyclohexanediamine / N,N-dimethyl-formamide / 12 - 16 h / 110 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; methanol

4.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 4 h

With potassium phosphate; copper(l) iodide; HATU; sodium hydroxide; trans-1,2-cyclohexanediamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 34633-08-4
(E)-ethyl 3-(4-iodophenyl)prop-2-enoate

: 1416891-66-1
(2E)-3-[4-[3-[2-[morpholin-4-yl]ethyl]-1H-indol-1-yl]phenyl]-N-[pyridin-3-ylmethyl]prop-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; copper(l) iodide; trans-1,2-cyclohexanediamine / N,N-dimethyl-formamide / 12 - 16 h / 110 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; methanol

3.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 4 h

With potassium phosphate; copper(l) iodide; HATU; sodium hydroxide; trans-1,2-cyclohexanediamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;