(7R)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate

Base Information

Chemical Name:(7R)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate
CAS No.:1315509-49-9
Molecular Formula:C₁₆H₁₉N₃O*C₁₈H₁₄O₈
Molecular Weight:627.651
Hs Code.:

Synonyms:(7R)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate

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Chemical Property of (7R)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate

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Technology Process of (7R)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate

There total 2 articles about (7R)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 2743-38-6
O,O'-dibenzoyl-L-tartaric acid

: 52100-24-0
(+/-)-7-amino-3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-one

: 1315509-49-9
(7R)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate

: 1315509-51-3
(7S)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate

Guidance literature:: In ethanol; at 20 ℃; for 120h; Resolution of racemate;
DOI:10.1016/j.tetasy.2011.03.010

Reference yield:

: 7-azido-3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-one

: 1315509-49-9
(7R)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate

: 1315509-51-3
(7S)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2R,3R)-2,3-bis-benzoyloxy-3-carboxy-propionate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 760.05 Torr

2: ethanol / 120 h / 20 °C / Resolution of racemate

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tetasy.2011.03.010