tert-butyl 3-((4-(5-amino-6-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-((4-(5-amino-6-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate
• CAS No.: 1432755-76-4
• Molecular Formula: C₂₈H₃₀N₆O₄S₂
• Molecular Weight: 578.716
• Mol file: 1432755-76-4.mol

Synonyms:tert-butyl 3-((4-(5-amino-6-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 3-((4-(5-amino-6-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-((4-(5-amino-6-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

There total 9 articles about tert-butyl 3-((4-(5-amino-6-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonylpiperidine-1-carboxylate (1427750-91-1) + 5-bromo-3-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-amine (1232423-51-6) → tert-butyl 3-((4-(5-amino-6-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate (1432755-76-4)

Guidance literature:

With 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

Carboxymethyl dithiobenzoate (942-91-6) → tert-butyl 3-((4-(5-amino-6-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate (1432755-76-4)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 4 h / 20 °C / Reflux

2: hydrogenchloride / ethanol / Reflux

3: 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; sodium carbonate / 1,4-dioxane / 0.5 h / 100 °C / Microwave irradiation

With hydrogenchloride; thionyl chloride; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; sodium carbonate; In 1,4-dioxane; ethanol;

Reference yield:

methyl 3-amino-6-bromopyrazine-2-carboxylate (6966-01-4) → tert-butyl 3-((4-(5-amino-6-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate (1432755-76-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 1,4-dioxane / 2 h / 20 - 60 °C

2: hydrogenchloride / ethanol / Reflux

3: 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; sodium carbonate / 1,4-dioxane / 0.5 h / 100 °C / Microwave irradiation

With hydrogenchloride; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; sodium carbonate; hydrazine hydrate; In 1,4-dioxane; ethanol;

upstream raw materials:

tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonylpiperidine-1-carboxylate

5-bromo-3-(5-phenyl-1,3,4-thiadiazol-2-yl)pyrazin-2-amine

methyl 3-amino-6-bromopyrazine-2-carboxylate

Carboxymethyl dithiobenzoate