4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride

Base Information

Chemical Name:4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride
CAS No.:1383377-49-8
Molecular Formula:C₁₇H₁₂FN₃O₂*ClH
Molecular Weight:345.761
Hs Code.:

Synonyms:4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride

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Chemical Property of 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride

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Technology Process of 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride

There total 11 articles about 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383376-92-8
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one

: 1383377-49-8
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; ethyl acetate;

Reference yield:

: 399-88-2
3-fluoro-4-methylpyridine

: 1383377-49-8
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 5 °C

1.2: 0 - 20 °C

2.1: tetrahydrofuran / 3 h / 80 - 100 °C

3.1: ethanol / 0 - 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C

5.1: triethylamine / acetonitrile / 96 h / 70 °C

6.1: dimethyl sulfoxide / 2 h / 50 °C

7.1: potassium hydroxide; water / 24 h / 100 °C

8.1: acetic anhydride; acetic acid / 3 h / 110 °C

9.1: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 1.5 h

9.2: 2 h / 110 °C

10.1: hydrogenchloride / ethyl acetate; diethyl ether

With hydrogenchloride; sodium tetrahydroborate; water; acetic anhydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile;

Reference yield:

: 1286230-78-1
3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1383377-49-8
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]pyridin-5(7H)-one monohydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2.1: dimethyl sulfoxide / 2 h / 50 °C

3.1: potassium hydroxide; water / 24 h / 100 °C

4.1: acetic anhydride; acetic acid / 3 h / 110 °C

5.1: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 1.5 h

5.2: 2 h / 110 °C

6.1: hydrogenchloride / ethyl acetate; diethyl ether

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium tetrahydroborate; water; acetic anhydride; caesium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;