C₂₁H₁₉F₂NO₅S

Base Information

• Chemical Name: C₂₁H₁₉F₂NO₅S
• CAS No.: 1100361-56-5
• Molecular Formula: C₂₁H₁₉F₂NO₅S
• Molecular Weight: 435.448
• Mol file: 1100361-56-5.mol

Synonyms:C₂₁H₁₉F₂NO₅S

Chemical Property of C₂₁H₁₉F₂NO₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₉F₂NO₅S

There total 10 articles about C₂₁H₁₉F₂NO₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

zinc(II) cyanide (557-21-1) + C20H19ClF2O5S (1100361-34-9) → C21H19F2NO5S (1100361-56-5)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In N,N-dimethyl-formamide; at 150 ℃;

DOI:10.1016/j.bmcl.2012.11.047

Reference yield:

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol (944950-53-2) → C21H19F2NO5S (1100361-56-5)

Guidance literature:

Multi-step reaction with 10 steps

1: potassium tert-butylate / tetrahydrofuran

2: Dess-Martin periodane / dichloromethane

3: trimethylsilyl trifluoromethanesulfonate

4: boron trifluoride diethyl etherate / dichloromethane

5: oxone / acetone; water

6: triethylamine / dichloromethane

7: potassium tert-butylate / tetrahydrofuran

8: ozone / dichloromethane

9: Resolution of racemate

10: zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 150 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; oxone; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; potassium tert-butylate; Dess-Martin periodane; ozone; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2012.11.047

Reference yield:

C16H13ClF2O2S → C21H19F2NO5S (1100361-56-5)

Guidance literature:

Multi-step reaction with 9 steps

1: Dess-Martin periodane / dichloromethane

2: trimethylsilyl trifluoromethanesulfonate

3: boron trifluoride diethyl etherate / dichloromethane

4: oxone / acetone; water

5: triethylamine / dichloromethane

6: potassium tert-butylate / tetrahydrofuran

7: ozone / dichloromethane

8: Resolution of racemate

9: zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 150 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; oxone; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; potassium tert-butylate; Dess-Martin periodane; ozone; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2012.11.047

upstream raw materials:

zinc(II) cyanide

C₂₀H₁₉ClF₂O₅S

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

p-Chlorothiophenol

Downstream raw materials:

C₂₈H₂₅F₂NO₇S₂