Technology Process of 2-bromo-2-(tetrahydro-2H-pyran-4-yl)acetonitrile
There total 1 articles about 2-bromo-2-(tetrahydro-2H-pyran-4-yl)acetonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / diethyl ether / 6 h / 20 °C / Inert atmosphere
2: hydrogenchloride; water / 2 h / Inert atmosphere
3: 1H-imidazole; dibromotriphenylphosphorane / dichloromethane / 0 - 20 °C / Inert atmosphere
With
1H-imidazole; hydrogenchloride; water; potassium carbonate; dibromotriphenylphosphorane;
In
diethyl ether; dichloromethane;
DOI:10.1021/ja303442q
- Guidance literature:
-
phenylmagnesium bromide;
With
zinc dimethoxide;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Inert atmosphere;
2-bromo-2-(tetrahydro-2H-pyran-4-yl)acetonitrile;
With
(1,2-dimethoxyethane)dichloronickel(II); N,N,N,N,-tetramethylethylenediamine; (4R,4'R)-2,2'-(cyclopentane-1,1-diyl)bis(4-isopropyl-4,5-dihydrooxazole);
In
tetrahydrofuran;
at -78 ℃;
for 48h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja303442q
- Guidance literature:
-
phenylmagnesium bromide;
With
zinc dimethoxide;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Inert atmosphere;
2-bromo-2-(tetrahydro-2H-pyran-4-yl)acetonitrile;
With
(1,2-dimethoxyethane)dichloronickel(II); N,N,N,N,-tetramethylethylenediamine; (4S,4'S)-2,2'-(cyclopentane-1,1-diyl)bis(4-iso-propyl-4,5-dihydrooxazole);
In
tetrahydrofuran;
at -78 ℃;
for 48h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja303442q
