1-[3-(4-Fluoro-phenyl)-1-(1-phenyl-ethyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone

Base Information

Chemical Name:1-[3-(4-Fluoro-phenyl)-1-(1-phenyl-ethyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone
CAS No.:95936-04-2
Molecular Formula:C₂₂H₂₂FN₃O
Molecular Weight:363.435
Hs Code.:

Synonyms:1-[3-(4-Fluoro-phenyl)-1-(1-phenyl-ethyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone

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Chemical Property of 1-[3-(4-Fluoro-phenyl)-1-(1-phenyl-ethyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone

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Technology Process of 1-[3-(4-Fluoro-phenyl)-1-(1-phenyl-ethyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone

There total 3 articles about 1-[3-(4-Fluoro-phenyl)-1-(1-phenyl-ethyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 95936-04-2
1-[3-(4-Fluoro-phenyl)-1-(1-phenyl-ethyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenesulfonic acid / benzene / 8 h / Heating

2: triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

3: 98percent hydrazine hydrate / aq. ethanol / 3 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 2 h

With sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; benzene;
DOI:10.1021/jm00145a015

Reference yield:

: 55459-60-4
1-(4-(morpholin-4-yl)-3,6-dihydro-2H-pyridin-1-yl)ethanone

: 95936-04-2
1-[3-(4-Fluoro-phenyl)-1-(1-phenyl-ethyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

2: 98percent hydrazine hydrate / aq. ethanol / 3 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 2 h

With sodium hydride; hydrazine hydrate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00145a015

Reference yield:

: 87642-26-0
1-Acetyl-3-(4-fluoro-benzoyl)-piperidin-4-one

: 95936-04-2
1-[3-(4-Fluoro-phenyl)-1-(1-phenyl-ethyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 98percent hydrazine hydrate / aq. ethanol / 3 h / Ambient temperature

2: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 2 h

With sodium hydride; hydrazine hydrate; In ethanol;
DOI:10.1021/jm00145a015