3-benzylpyrimido<6,5-i>imidazo<4,5-g>-9H-cinnolin-10-one

Base Information

Chemical Name:3-benzylpyrimido<6,5-i>imidazo<4,5-g>-9H-cinnolin-10-one
CAS No.:96228-59-0
Molecular Formula:C₁₈H₁₂N₆O
Molecular Weight:328.333
Hs Code.:

Synonyms:3-benzylpyrimido<6,5-i>imidazo<4,5-g>-9H-cinnolin-10-one

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Chemical Property of 3-benzylpyrimido<6,5-i>imidazo<4,5-g>-9H-cinnolin-10-one

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Technology Process of 3-benzylpyrimido<6,5-i>imidazo<4,5-g>-9H-cinnolin-10-one

There total 11 articles about 3-benzylpyrimido<6,5-i>imidazo<4,5-g>-9H-cinnolin-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 96228-57-8
7-amino-3-benzylimidazo<4,5-g>cinnoline-8-carboxamide

: 109-94-4
formic acid ethyl ester

: 96228-59-0
3-benzylpyrimido<6,5-i>imidazo<4,5-g>-9H-cinnolin-10-one

Guidance literature:: With sodium; In ethanol; for 3h; Heating;
DOI:10.1021/jo00214a011

Reference yield:

: 96228-48-7
2-acetamido-4-chloro-5-nitroacetophenone

: 96228-59-0
3-benzylpyrimido<6,5-i>imidazo<4,5-g>-9H-cinnolin-10-one

Guidance literature:: Multi-step reaction with 10 steps

1: 86 percent / butan-1-ol / 4 h / Heating

2: H₂ / Raney Ni / dimethylformamide; aq. NH₃ / 2 h / 25 °C / 2280 Torr

3: 80 percent / HCOOH / 3 h / Heating

4: 92 percent / aq. HCl / ethanol / 1.5 h / Heating

6: 80 percent / isoamyl nitrite / ethanol; HCl / 1.) 0 deg C, 30 min, 2.) 25 deg C, 16 h

7: 76 percent / acetic anhydride / 1 h / 140 °C

8: SnCl₂*2H₂O, 12N HCl / H₂O / 1.) 0 deg C, 2 h, 2.) 25 deg C, 16 h

9: KOH / H₂O; ethanol / 2 h / Heating

10: 85 percent / Na / ethanol / 3 h / Heating

With hydrogenchloride; potassium hydroxide; formic acid; hydrogen; sodium; acetic anhydride; tin(ll) chloride; isopentyl nitrite; nickel; In hydrogenchloride; ammonium hydroxide; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jo00214a011

Reference yield:

: 96228-49-8
2-acetamido-4-(benzylamino)-5-nitroacetophenone

: 96228-59-0
3-benzylpyrimido<6,5-i>imidazo<4,5-g>-9H-cinnolin-10-one

Guidance literature:: Multi-step reaction with 9 steps

1: H₂ / Raney Ni / dimethylformamide; aq. NH₃ / 2 h / 25 °C / 2280 Torr

2: 80 percent / HCOOH / 3 h / Heating

3: 92 percent / aq. HCl / ethanol / 1.5 h / Heating

5: 80 percent / isoamyl nitrite / ethanol; HCl / 1.) 0 deg C, 30 min, 2.) 25 deg C, 16 h

6: 76 percent / acetic anhydride / 1 h / 140 °C

7: SnCl₂*2H₂O, 12N HCl / H₂O / 1.) 0 deg C, 2 h, 2.) 25 deg C, 16 h

8: KOH / H₂O; ethanol / 2 h / Heating

9: 85 percent / Na / ethanol / 3 h / Heating

With hydrogenchloride; potassium hydroxide; formic acid; hydrogen; sodium; acetic anhydride; tin(ll) chloride; isopentyl nitrite; nickel; In hydrogenchloride; ammonium hydroxide; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00214a011