tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate
CAS No.:1610523-40-4
Molecular Formula:C₃₃H₃₄N₂O₇
Molecular Weight:570.642
Hs Code.:

Synonyms:tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

: 1610522-98-9
7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carboxylic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1610523-40-4
tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1039/c4ob00364k

Reference yield:

: 627872-67-7
3,4-bis(benzyloxy)-2-hydroxybenzaldehyde

: 1610523-40-4
tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: piperdinium acetate / ethanol / 24 h / 60 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C

With dmap; piperdinium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1039/c4ob00364k

Reference yield:

: 2144-08-3
2,3,4-trihydroxybenzylaldehyde

: 1610523-40-4
tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 60 °C

2.1: magnesium bromide ethyl etherate / diethyl ether / 20 °C

2.2: 0 °C

3.1: piperdinium acetate / ethanol / 24 h / 60 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C

With dmap; piperdinium acetate; potassium carbonate; magnesium bromide ethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c4ob00364k